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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1588588
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbk1
Name: TANK-binding kinase 1
Acc ID: CHEBI:31205
Term: amlexanox
Definition: A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Chemical ID: MESH:C045742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbk1decreases activityISORGD:13137526480464CTDamlexanox results in decreased activity of TBK1 protein

PMID:25321315
Tbk1decreases phosphorylationISORGD:13137536480464CTDamlexanox results in decreased phosphorylation of TBK1 protein

PMID:31697998
Tbk1multiple interactionsISORGD:13137536480464CTDamlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of TBK1 protein]

PMID:31697998
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.