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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2674
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gdf15
Name: growth differentiation factor 15
Acc ID: CHEBI:31159
Term: aceclofenac
Definition: A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Chemical ID: MESH:C056498
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdf15increases expressionISOGDF15 (Homo sapiens)6480464CTDaceclofenac results in increased expression of GDF15 proteinPMID:15555568
Gdf15increases expressionISOGdf15 (Mus musculus)6480464CTDaceclofenac results in increased expression of GDF15 mRNAPMID:18076062
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