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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3700
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Acc ID: CHEBI:310312
Term: isoliquiritigenin
Definition: A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Chemical ID: MESH:C040920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco1a1decreases activityEXP 6480464CTDisoliquiritigenin results in decreased activity of SLCO1B1 protein

PMID:32259555
Slco1a1multiple interactionsEXP 6480464CTD[isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan, [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate

PMID:32259555
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