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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkbia
Name: NFKB inhibitor alpha
Acc ID: CHEBI:310312
Term: isoliquiritigenin
Definition: A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Chemical ID: MESH:C040920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiadecreases phosphorylationISORGD:7354406480464CTDisoliquiritigenin results in decreased phosphorylation of NFKBIA protein

PMID:15729620
Nfkbiaincreases expressionISORGD:7354406480464CTDisoliquiritigenin results in increased expression of NFKBIA protein

PMID:15729620
Nfkbiamultiple interactionsISORGD:109756480464CTDisoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein]

PMID:18295200
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.