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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:310312
Term: isoliquiritigenin
Definition: A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Chemical ID: MESH:C040920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsISORGD:7374876480464CTDisoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]

PMID:26134484
Ifngmultiple interactionsISORGD:7374886480464CTDisoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein], isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]

PMID:23942037, PMID:25026504
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.