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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:3093
Term: bifenthrin
Definition: A carboxylic ester obtained by formal condensation of cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylic acid and [(2-methyl-1,1'-biphenyl)-3-yl]methanol.
Chemical ID: MESH:C099952
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2increases expressionEXP 6480464CTDbifenthrin results in increased expression of PTGS2 mRNA; bifenthrin results in increased expression of PTGS2 proteinPMID:32061760
PTGS2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTDbifenthrin results in increased expression of PTGS2 mRNA; bifenthrin results in increased expression of PTGS2 proteinPMID:29775722 PMID:29793499 PMID:30102949
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTDbifenthrin analog inhibits the reaction [CGA results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [Colforsin results in increased expression of PTGS2 mRNA]PMID:21251947 PMID:21871944
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