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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737444
Species: Mus musculus
RGD Object: Gene
Symbol: Gabrg1
Name: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
Acc ID: CHEBI:3092
Term: bicuculline
Definition: Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Chemical ID: MESH:D001640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:6217326480464CTDBicuculline results in decreased expression of GABRG1 mRNA

PMID:9600394
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.