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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731547
Species: Homo sapiens
RGD Object: Gene
Symbol: GRIA1
Name: glutamate ionotropic receptor AMPA type subunit 1
Acc ID: CHEBI:3092
Term: bicuculline
Definition: A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Chemical ID: MESH:D001640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GRIA1multiple interactionsISOGria1 (Rattus norvegicus)6480464CTDBicuculline results in decreased expression of and results in decreased localization of GRIA1 proteinPMID:19674091
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