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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62037
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arc
Name: activity-regulated cytoskeleton-associated protein
Acc ID: CHEBI:3092
Term: bicuculline
Definition: A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Chemical ID: MESH:D001640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arcmultiple interactionsEXP 6480464CTDBicuculline inhibits the reaction [Propofol results in decreased expression of ARC protein]

PMID:18946287
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