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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2740
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grin2d
Name: glutamate ionotropic receptor NMDA type subunit 2D
Acc ID: CHEBI:3092
Term: bicuculline
Definition: A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Chemical ID: MESH:D001640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin2dmultiple interactionsISORGD:7327196480464CTD[Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein

PMID:19911010
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