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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621575
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdac1
Name: voltage-dependent anion channel 1
Acc ID: CHEBI:3087
Term: betulinic acid
Definition: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
Chemical ID: MESH:C002070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdac1decreases response to substanceISOVDAC1 (Homo sapiens)6480464CTDVDAC1 protein results in decreased susceptibility to Betulinic AcidPMID:30136359
Vdac1increases expressionISOVDAC1 (Homo sapiens)6480464CTDBetulinic Acid results in increased expression of VDAC1 proteinPMID:30136359
Vdac1multiple interactionsISOVDAC1 (Homo sapiens)6480464CTD[VDAC1 protein results in decreased susceptibility to Betulinic Acid] which results in increased expression of HK2 protein; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP3 protein modified form]; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP7 protein modified form]PMID:30136359
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