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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:3086
Term: betulin
Definition: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.
Chemical ID: MESH:C002503
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDbetulin results in increased cleavage of CASP3 proteinPMID:32190974
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDChloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]PMID:32190974
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