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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735826
Species: Homo sapiens
RGD Object: Gene
Symbol: GAST
Name: gastrin
Acc ID: CHEBI:3084
Term: bethanechol
Definition: The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Chemical ID: MESH:D018723
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GASTincreases secretionISOGast (Rattus norvegicus)6480464CTDBethanechol results in increased secretion of GAST proteinPMID:19296048
GASTmultiple interactionsISOGast (Rattus norvegicus)6480464CTDCALCA protein inhibits the reaction [Bethanechol results in increased secretion of GAST protein]PMID:19296048
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