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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10812
Species: Mus musculus
RGD Object: Gene
Symbol: Ins2
Name: insulin II
Acc ID: CHEBI:30816
Term: vanillic acid
Definition: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.
Chemical ID: MESH:D014641
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTDVanillic Acid affects the reaction [INS protein results in increased expression of PRKCB protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased activity of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of ATP6 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of BAD protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of FGF21 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GYS1 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of HSPA9 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of IDE protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of IRS2 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of MFN2 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]; Vanillic Acid inhibits the reaction [INS protein results in increased activity of DGAT2 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of DDIT3 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of FASN protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of G6PC1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of GCKR protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of HSPA5 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of IRS1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of ITPR1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of MAPK8 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of PPARG protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of SCD protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of SREBF1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of XBP1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein]PMID:33651899 PMID:36764371
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