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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:30772
Term: butyric acid
Definition: A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Chemical ID: MESH:D020148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDButyric Acid results in increased phosphorylation of MAPK1 proteinPMID:28600122
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[1'-acetoxychavicol acetate co-treated with Butyric Acid] results in increased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Butyric Acid results in increased phosphorylation of MAPK1 protein]PMID:24480522 PMID:28600122
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