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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359422
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srsf2
Name: serine and arginine rich splicing factor 2
Acc ID: CHEBI:30772
Term: butyric acid
Definition: A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Chemical ID: MESH:D020148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srsf2decreases phosphorylationISOSRSF2 (Homo sapiens)6480464CTDButyric Acid results in decreased phosphorylation of SRSF2 proteinPMID:21555914
Srsf2increases expressionISOSRSF2 (Homo sapiens)6480464CTD[Butyric Acid results in increased expression of SRSF2 protein] which results in increased expression of CDKN1A mRNA; [Butyric Acid results in increased expression of SRSF2 protein] which results in increased expression of CDKN1A protein; Butyric Acid results in increased expression of SRSF2 proteinPMID:21555914
Srsf2multiple interactionsISOSRSF2 (Homo sapiens)6480464CTDButyric Acid promotes the reaction [KAT5 protein results in increased acetylation of SRSF2 protein]; Butyric Acid promotes the reaction [SRSF2 protein binds to HDAC6 protein]; Butyric Acid promotes the reaction [SRSF2 protein binds to KAT5 protein]; HDAC6 protein promotes the reaction [Butyric Acid results in increased expression of SRSF2 protein]; KAT5 protein promotes the reaction [Butyric Acid results in increased expression of SRSF2 protein]PMID:21555914
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