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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593189
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta5
Name: glutathione S-transferase alpha 5
Acc ID: CHEBI:30725
Term: aflatoxin B1 exo-8,9-epoxide
Definition: An aflatoxin that has formula C17H12O7.
Chemical ID: MESH:C006426
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta5affects metabolic processingEXP 6480464CTDGSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxidePMID:12388831 PMID:1637297 PMID:8625305 PMID:8761455
Gsta5multiple interactionsEXP 6480464CTD[GSTA3 protein binds to GSTA5 protein] which affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; Butylated Hydroxyanisole promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; GSTA5 protein affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; GSTA5 protein binds to and affects the metabolism of aflatoxin B1-2,3-oxide; Phenobarbital promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]PMID:10085232 PMID:8051171 PMID:8198522
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