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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736488
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNE1
Name: cyclin E1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNE1affects expressionEXP 6480464CTDArsenic Trioxide affects the expression of CCNE1 proteinPMID:12962562
CCNE1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of CCNE1 mRNA; Arsenic Trioxide results in decreased expression of CCNE1 proteinPMID:12480548 PMID:19236751 PMID:34042274 PMID:34413873
CCNE1decreases methylationEXP 6480464CTDArsenic Trioxide results in decreased methylation of CCNE1 promoterPMID:29159499
CCNE1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of CCNE1 mRNA; Arsenic Trioxide results in increased expression of CCNE1 proteinPMID:29159499 PMID:29633893
CCNE1multiple interactionsEXP 6480464CTDArsenic Trioxide promotes the reaction [CCNE1 protein binds to CDKN1A protein]; TP53 protein promotes the reaction [Arsenic Trioxide results in decreased expression of CCNE1 protein]PMID:10850458 PMID:34042274
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