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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733985
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2A1
Name: BCL2 related protein A1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2A1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of BCL2A1 mRNAPMID:19128835
BCL2A1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of BCL2A1 mRNAPMID:10673743 PMID:17530438
BCL2A1multiple interactionsEXP 6480464CTD[Tretinoin co-treated with Arsenic Trioxide co-treated with Butyrates] results in increased expression of BCL2A1 mRNA; [Tretinoin co-treated with Arsenic Trioxide co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of BCL2A1 mRNA; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of BCL2A1A protein]PMID:11133770 PMID:12130515 PMID:15894607
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