GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tert | decreases activity | ISO | TERT (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of TERT mRNA; Arsenic Trioxide results in decreased activity of TERT protein | PMID:12962562 PMID:15228664 PMID:15996315 PMID:17275888 PMID:22693909 PMID:22944098 | Tert | decreases activity | ISO | Tert (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of TERT protein | PMID:18336854 | Tert | decreases expression | ISO | TERT (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of TERT gene; Arsenic Trioxide results in decreased expression of TERT mRNA; Arsenic Trioxide results in decreased expression of TERT protein | PMID:11714746 PMID:15228664 PMID:15761015 PMID:16129045 PMID:16285558 PMID:16966277 PMID:17275888 PMID:17956674 PMID:21544632 PMID:22693909 PMID:22944098 PMID:23851143 PMID:25436934 PMID:27039805 PMID:30316766 PMID:31539632 | Tert | multiple interactions | ISO | TERT (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with VS-5584] results in decreased expression of TERT mRNA; [Arsenic Trioxide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of TERT mRNA; [BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of TERT mRNA; [NVP-BKM120 co-treated with Arsenic Trioxide] results in decreased expression of TERT mRNA; Arsenic Trioxide inhibits the reaction [SP1 protein binds to TERT promoter]; Arsenic Trioxide inhibits the reaction [SP1 protein results in increased expression of TERT mRNA]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased activity of TERT protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of TERT mRNA]; GH1 protein promotes the reaction [Arsenic Trioxide results in decreased expression of TERT mRNA]; NVP-BKM120 promotes the reaction [Arsenic Trioxide results in decreased expression of TERT mRNA]; TERT protein results in decreased susceptibility to [Arsenic Trioxide co-treated with Tretinoin] | PMID:11714746 PMID:15761015 PMID:16107885 PMID:18336854 PMID:23851143 PMID:29574283 PMID:30316766 PMID:31539632 PMID:32645343 | Tert | multiple interactions | ISO | Tert (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of TERT protein]; CAT protein inhibits the reaction [Arsenic Trioxide results in decreased activity of TERT protein]; diphenyleneiodonium inhibits the reaction [Arsenic Trioxide results in decreased activity of TERT protein] | PMID:18336854 | | ||||||||||||||||||||||
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