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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70373
Species: Homo sapiens
RGD Object: Gene
Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BAXaffects expressionEXP 6480464CTDArsenic Trioxide affects the expression of BAX; Arsenic Trioxide affects the expression of BAX proteinPMID:11775218 PMID:16010437 PMID:16867262
BAXaffects localizationEXP 6480464CTDArsenic Trioxide affects the localization of BAX proteinPMID:17673311 PMID:20408844 PMID:20605902 PMID:21889928
BAXdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of BAX mRNA; Arsenic Trioxide results in decreased expression of BAX proteinPMID:11940349 PMID:16882451 PMID:18349030
BAXincreases activityEXP 6480464CTDArsenic Trioxide results in increased activity of BAX proteinPMID:15665116 PMID:18359480
BAXincreases cleavageEXP 6480464CTDArsenic Trioxide results in increased cleavage of BAX proteinPMID:16020671
BAXincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of BAX; Arsenic Trioxide results in increased expression of BAX mRNA; Arsenic Trioxide results in increased expression of BAX proteinPMID:11135700 PMID:12429934 PMID:12883267 PMID:15142122 PMID:17203211 PMID:17258074 PMID:19208092 PMID:19364129 PMID:19489279 PMID:19695276 PMID:19769630 PMID:20164150 PMID:20200477 PMID:20219070 PMID:20403207 PMID:20458559 PMID:21061466 PMID:21418039 PMID:21594580 PMID:23337567 PMID:23382965 PMID:23851143 PMID:24466103 PMID:24944602 PMID:24956101 PMID:24993472 PMID:25174355 PMID:25416439 PMID:25972196 PMID:26772155 PMID:27039805 PMID:27430728 PMID:27561292 PMID:29274334 PMID:30091188 PMID:30333888 PMID:30472098 PMID:31079498 PMID:31205918 PMID:32642412 PMID:34413873
BAXincreases response to substanceEXP 6480464CTDBAX results in increased susceptibility to Arsenic TrioxidePMID:18412143
BAXmultiple interactionsEXP 6480464CTD2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Arsenic Trioxide affects the localization of BAX protein]; 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [Arsenic Trioxide co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased activity of BAX protein; [Arsenic Trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in increased expression of BAX protein; [Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of BAX mRNA; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of BAX protein; [Arsenic Trioxide co-treated with NVP-BKM120] results in increased expression of BAX mRNA; [Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; [Arsenic Trioxide results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]; [Bortezomib co-treated with Arsenic Trioxide] affects the expression of BAX protein; [CpG ODN 2216 co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Docosahexaenoic Acids co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [MARVELD1 protein results in decreased susceptibility to Arsenic Trioxide] which results in decreased expression of BAX protein; [NVP-BKM120 co-treated with Arsenic Trioxide] results in increased expression of BAX mRNA; [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BAX mRNA; [tetraarsenic tetrasulfide co-treated with Arsenic Trioxide] results in increased expression of BAX mRNA; [tetraarsenic tetrasulfide co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of BAX mRNA; [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; allicin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Arsenic Trioxide inhibits the reaction [BCL2 protein binds to BAX protein binds to VDAC1 protein]; Arsenic Trioxide inhibits the reaction [BCL2 protein binds to BAX protein]; Arsenic Trioxide promotes the reaction [Aprepitant results in increased expression of BAX mRNA]; Arsenic Trioxide promotes the reaction [BAX protein binds to BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Arsenic Trioxide promotes the reaction [Genistein results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Quercetin results in increased activity of BAX protein]; Arsenic Trioxide results in increased activity of and affects the localization of BAX protein; Arsenic Trioxide results in increased cleavage of and results in increased expression of BAX protein; Arsenic Trioxide results in increased localization of and results in increased activity of BAX protein; BAX mutant form inhibits the reaction [Arsenic Trioxide affects the localization of AIFM1 protein]; BCL2 protein inhibits the reaction [Arsenic Trioxide inhibits the reaction [BCL2 protein binds to BAX protein]]; BCL2 protein inhibits the reaction [Arsenic Trioxide results in increased activity of BAX protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Arsenic Trioxide results in increased cleavage of BAX protein]; calpeptin inhibits the reaction [Arsenic Trioxide results in increased cleavage of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Deoxyglucose promotes the reaction [Arsenic Trioxide results in increased localization of and results in increased activity of BAX protein]; Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; Genistein promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]; GH1 protein promotes the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; ID1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; MAPK14 mutant form inhibits the reaction [Arsenic Trioxide affects the localization of BAX protein]; MARVELD1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; MT2A protein inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of and results in increased localization of BAX protein]; Quercetin promotes the reaction [Arsenic Trioxide results in increased activity of BAX protein]; Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased localization of BAX protein]; TNF protein promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; U 0126 promotes the reaction [Arsenic Trioxide results in increased activity of and results in increased localization of BAX protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]PMID:12609832 PMID:15131059 PMID:15142122 PMID:15665116 PMID:15735709 PMID:16972261 PMID:17237268 PMID:17374990 PMID:17673311 PMID:18359480 PMID:18412143 PMID:18718063 PMID:20219070 PMID:20605902 PMID:23041229 PMID:23664956 PMID:23851143 PMID:24126434 PMID:24738333 PMID:24956101 PMID:25815518 PMID:26110921 PMID:26772155 PMID:27430728 PMID:27561292 PMID:29274334 PMID:30012499 PMID:30145367 PMID:30316766 PMID:31079498 PMID:31205918 PMID:31539632 PMID:32642412 PMID:36352148
BAXaffects expressionISOBax (Rattus norvegicus)6480464CTDArsenic Trioxide affects the expression of BAX proteinPMID:12725324 PMID:23337567
BAXaffects localizationISOBax (Mus musculus)6480464CTDArsenic Trioxide affects the localization of BAX proteinPMID:27461142
BAXaffects response to substanceISOBax (Mus musculus)6480464CTDBAX protein affects the susceptibility to Arsenic TrioxidePMID:15979664
BAXdecreases expressionISOBax (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of BAX proteinPMID:10712780
BAXincreases expressionISOBax (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of BAX mRNA; Arsenic Trioxide results in increased expression of BAX proteinPMID:21533816 PMID:21565247 PMID:23664956 PMID:23892647 PMID:24157283 PMID:25787108 PMID:28454374 PMID:33603344 PMID:33846815 PMID:34333357 PMID:35317438 PMID:35676786 PMID:36707890
BAXincreases expressionISOBax (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of BAX mRNA; Arsenic Trioxide results in increased expression of BAX proteinPMID:19260322 PMID:23201927 PMID:23337567 PMID:23542815 PMID:28391263 PMID:29610575 PMID:30551535 PMID:31258454 PMID:32096187 PMID:32919218 PMID:32920515 PMID:33173984 PMID:34037972 PMID:35195477
BAXmultiple interactionsISOBax (Mus musculus)6480464CTD18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; Arsenic Trioxide results in increased expression of and affects the localization of BAX protein; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of and affects the localization of BAX protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; MIR34A affects the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Propranolol inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]PMID:21533816 PMID:23892647 PMID:27638049 PMID:33603344 PMID:33846815 PMID:34333357 PMID:35317438 PMID:36707890
BAXmultiple interactionsISOBax (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; HTS 466284 inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]PMID:23201927 PMID:23542815 PMID:28391263 PMID:32919218 PMID:32920515 PMID:33173984 PMID:34037972 PMID:35195477
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