GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TGFB1 | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of TGFB1 protein | PMID:29950232 | TGFB1 | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of TGFB1 mRNA; Arsenic Trioxide results in increased expression of TGFB1 protein | PMID:12859871 PMID:19236751 PMID:20723295 PMID:31734849 PMID:32240679 PMID:34108876 | TGFB1 | increases secretion | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased secretion of TGFB1 protein | PMID:34108876 | TGFB1 | multiple interactions | EXP | | 6480464 | CTD | Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; Arsenic Trioxide promotes the reaction [TGFB1 protein results in decreased expression of BCL2 protein]; Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; PML protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 protein]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 mRNA]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 protein]; TGFB1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of MIR182 mRNA]; TGFB1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of MIR183 mRNA]; TGFB1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of MIR96 mRNA]; UBE2I protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 mRNA]; UBE2I protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 protein] | PMID:20723295 PMID:24762191 PMID:25196641 PMID:29662624 PMID:30317545 PMID:32240679 PMID:35276128 | TGFB1 | affects expression | ISO | Tgfb1 (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide affects the expression of TGFB1 mRNA | PMID:31734849 | TGFB1 | affects expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide affects the expression of TGFB1 mRNA | PMID:19545743 | TGFB1 | decreases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of TGFB1 mRNA; Arsenic Trioxide results in decreased expression of TGFB1 protein | PMID:23210436 PMID:27461142 PMID:28454374 | TGFB1 | increases expression | ISO | Tgfb1 (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of TGFB1 protein | PMID:23542815 | TGFB1 | increases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of TGFB1 mRNA | PMID:23802174 | TGFB1 | multiple interactions | ISO | Tgfb1 (Rattus norvegicus) | 6480464 | CTD | [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA] | PMID:31612257 | TGFB1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | 2-aminoethoxydiphenyl borate inhibits the reaction [Arsenic Trioxide results in decreased expression of TGFB1 mRNA]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in decreased expression of TGFB1 mRNA]; [Arsenic Trioxide co-treated with Cyclosporine] affects the expression of TGFB1 mRNA; ATF4 protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 mRNA]; Quin2 inhibits the reaction [Arsenic Trioxide results in decreased expression of TGFB1 mRNA] | PMID:19545743 PMID:27461142 | | ||||||||||||||||||||||
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