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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of MTOR proteinPMID:25416439
MTORdecreases phosphorylationEXP 6480464CTDArsenic Trioxide results in decreased phosphorylation of MTOR proteinPMID:21594580 PMID:25449439
MTORincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of MTOR mRNAPMID:29633893
MTORmultiple interactionsEXP 6480464CTDArsenic Trioxide inhibits the reaction [Sorafenib results in increased expression of MTOR protein]PMID:25416439
MTORaffects expressionISOMtor (Mus musculus)6480464CTDArsenic Trioxide affects the expression of MTOR mRNAPMID:32112876 PMID:32781346
MTORdecreases expressionISOMtor (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of MTOR mRNA; Arsenic Trioxide results in decreased expression of MTOR proteinPMID:30032600 PMID:30225639 PMID:32781346
MTORdecreases phosphorylationISOMtor (Mus musculus)6480464CTDArsenic Trioxide results in decreased phosphorylation of MTOR proteinPMID:33462182
MTORmultiple interactionsISOMtor (Mus musculus)6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MTOR protein]; Sirolimus promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of MTOR protein]PMID:33462182
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