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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628662
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a3
Name: aldehyde dehydrogenase 1 family, member A3
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a3decreases expressionISOALDH1A3 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of ALDH1A3 mRNAPMID:26705709
Aldh1a3increases expressionISOALDH1A3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ALDH1A3 proteinPMID:25419056
Aldh1a3multiple interactionsISOALDH1A3 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ALDH1A3 protein]PMID:26598702
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