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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek2increases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of CHEK2 proteinPMID:23337567
Chek2multiple interactionsEXP 6480464CTD2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK2 protein]PMID:23337567
Chek2increases expressionISOCHEK2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CHEK2 mRNAPMID:22521957
Chek2multiple interactionsISOCHEK2 (Homo sapiens)6480464CTD[ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of CHEK2 protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein]PMID:16891316 PMID:18482988 PMID:30012499
Chek2multiple interactionsISOChek2 (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 proteinPMID:16891316
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