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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptch1
Name: patched 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptch1multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]; Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]PMID:31612257
Ptch1decreases expressionISOPTCH1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of PTCH1 mRNAPMID:23861973 PMID:24685274
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