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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ikbkb
Name: inhibitor of nuclear factor kappa B kinase subunit beta
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ikbkbdecreases expressionISOIKBKB (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of IKBKB mRNA; Arsenic Trioxide results in decreased expression of IKBKB proteinPMID:19763917 PMID:22988968
Ikbkbincreases expressionISOIKBKB (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of IKBKB mRNAPMID:29633893
Ikbkbmultiple interactionsISOIKBKB (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased phosphorylation of and results in increased activity of IKBKB protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of IKBKB protein; TNF protein inhibits the reaction [Arsenic Trioxide results in decreased expression of IKBKB mRNA]; TNF protein inhibits the reaction [Arsenic Trioxide results in decreased expression of IKBKB protein]PMID:22988968 PMID:23949314
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