GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ikbkb | decreases expression | ISO | IKBKB (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of IKBKB mRNA; Arsenic Trioxide results in decreased expression of IKBKB protein | PMID:19763917 PMID:22988968 | Ikbkb | increases expression | ISO | IKBKB (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of IKBKB mRNA | PMID:29633893 | Ikbkb | multiple interactions | ISO | IKBKB (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of IKBKB protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of IKBKB protein; TNF protein inhibits the reaction [Arsenic Trioxide results in decreased expression of IKBKB mRNA]; TNF protein inhibits the reaction [Arsenic Trioxide results in decreased expression of IKBKB protein] | PMID:22988968 PMID:23949314 | |
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