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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDArsenic Trioxide results in decreased activity of CAT proteinPMID:16214333 PMID:23023136 PMID:23283742 PMID:24095718 PMID:26184899 PMID:26560635 PMID:27713174 PMID:28209094 PMID:28391263 PMID:28978146 PMID:29130132 PMID:32920515 PMID:33173984
Catdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of CAT mRNA; Arsenic Trioxide results in decreased expression of CAT proteinPMID:29223816 PMID:32919218
Catdecreases response to substanceEXP 6480464CTDCAT protein results in decreased susceptibility to Arsenic TrioxidePMID:22590507
Catmultiple interactionsEXP 6480464CTD[boric acid co-treated with Arsenic Trioxide] affects the activity of CAT protein; crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; Folic Acid inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; Linseed Oil inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; naringenin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; oxymatrine inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; polydatin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; salvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Vitamin B 12 promotes the reaction [Folic Acid inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]]PMID:16214333 PMID:23023136 PMID:23283742 PMID:26184899 PMID:27713174 PMID:28209094 PMID:28391263 PMID:28978146 PMID:29130132 PMID:32919218 PMID:32920515 PMID:33173984
Catdecreases activityISOCAT (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of CAT proteinPMID:21308489 PMID:29751151 PMID:33634982
Catdecreases activityISOCat (Mus musculus)6480464CTDArsenic Trioxide results in decreased activity of CAT proteinPMID:18332854 PMID:18715643 PMID:25542264 PMID:33603344 PMID:33846815 PMID:34333357 PMID:35317438
Catdecreases expressionISOCAT (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CAT mRNA; Arsenic Trioxide results in decreased expression of CAT proteinPMID:18588940 PMID:21308489 PMID:28803342 PMID:29467594
Catdecreases expressionISOCat (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of CAT proteinPMID:28803342
Catdecreases response to substanceISOCAT (Homo sapiens)6480464CTDCAT protein results in decreased susceptibility to Arsenic TrioxidePMID:11749846 PMID:17258074
Catincreases activityISOCat (Mus musculus)6480464CTDArsenic Trioxide results in increased activity of CAT proteinPMID:31846860
Catincreases response to substanceISOCAT (Homo sapiens)6480464CTDCAT results in increased susceptibility to Arsenic TrioxidePMID:21689642
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTD[Cisplatin co-treated with Arsenic Trioxide] results in decreased activity of CAT protein; [Fluorouracil co-treated with Arsenic Trioxide] results in decreased activity of CAT protein; [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CAT mRNA; CAT mutant form promotes the reaction [Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; CAT protein inhibits the reaction [[Arsenic Trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein]; CAT protein inhibits the reaction [Arsenic Trioxide results in increased expression of PTGS2 mRNA]; CAT protein results in decreased susceptibility to [Arsenic Trioxide co-treated with Ascorbic Acid]; Docosahexaenoic Acids inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; Grape Seed Proanthocyanidins inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]PMID:18387645 PMID:18588940 PMID:20171736 PMID:23082001 PMID:28803342 PMID:29751151 PMID:30012499 PMID:33634982
Catmultiple interactionsISOCat (Mus musculus)6480464CTD18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; Arsenic Trioxide affects the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; baicalin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; CAT protein inhibits the reaction [Arsenic Trioxide results in decreased activity of TERT protein]; CAT protein inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]PMID:18332854 PMID:18336854 PMID:18715643 PMID:25542264 PMID:28803342 PMID:30090573 PMID:33603344 PMID:33846815 PMID:34333357 PMID:35317438
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