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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350637
Species: Homo sapiens
RGD Object: Gene
Symbol: TOP2B
Name: DNA topoisomerase II beta
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TOP2Bincreases response to substanceEXP 6480464CTDTOP2B protein results in increased susceptibility to Arsenic Trioxide

PMID:20707922
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.