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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346665
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF10B
Name: TNF receptor superfamily member 10b
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF10Baffects response to substanceEXP 6480464CTDTNFRSF10B affects the susceptibility to Arsenic TrioxidePMID:18172319
TNFRSF10Bincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of TNFRSF10B; Arsenic Trioxide results in increased expression of TNFRSF10B mRNA; Arsenic Trioxide results in increased expression of TNFRSF10B proteinPMID:12851490 PMID:16434995 PMID:18172319 PMID:19939880 PMID:24345465 PMID:24377552 PMID:26705709 PMID:27430728
TNFRSF10Bmultiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Buthionine Sulfoximine] results in increased expression of TNFRSF10B protein; [Arsenic Trioxide co-treated with Curcumin] results in increased expression of TNFRSF10B protein; [Bortezomib co-treated with Arsenic Trioxide] results in increased expression of TNFRSF10B protein; [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of TNFRSF10B mRNA; [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of TNFRSF10B protein; Bortezomib promotes the reaction [Arsenic Trioxide results in increased activity of TNFRSF10B]; DDIT3 affects the reaction [Arsenic Trioxide results in increased expression of TNFRSF10B]; DDIT3 mutant form inhibits the reaction [Arsenic Trioxide results in increased expression of TNFRSF10B protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Buthionine Sulfoximine] results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [Arsenic Trioxide results in increased expression of TNFRSF10B protein]PMID:12851490 PMID:17145888 PMID:18172319 PMID:19939880 PMID:20471514 PMID:24345465 PMID:24377552 PMID:27430728
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