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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1affects localizationEXP 6480464CTDArsenic Trioxide affects the localization of PARP1 protein modified formPMID:15131059
PARP1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of PARP1 proteinPMID:19695276 PMID:25419056
PARP1increases activityEXP 6480464CTDArsenic Trioxide results in increased activity of PARP1 proteinPMID:11304686
PARP1increases cleavageEXP 6480464CTDArsenic Trioxide results in increased cleavage of PARP1 proteinPMID:10382944 PMID:10477740 PMID:10648417 PMID:10850458 PMID:11146441 PMID:11739184 PMID:12148893 PMID:12181429 PMID:12429934 PMID:12883267 PMID:12931215 PMID:14632209 PMID:15314284 PMID:15493360 PMID:16328441 PMID:16646077 PMID:18022205 PMID:18539383 PMID:19364129 PMID:19371599 PMID:19468689 PMID:20435036 PMID:20723298 PMID:20953137 PMID:20977926 PMID:21454520 PMID:21594580 PMID:21649584 PMID:22496356 PMID:22532027 PMID:23700110 PMID:23861973 PMID:25174355 PMID:25246272 PMID:25574600 PMID:25791921 PMID:26160715 PMID:29266867 PMID:29774349 PMID:29944906 PMID:30338810 PMID:31205918 PMID:32305283 PMID:34303041
PARP1increases degradationEXP 6480464CTDArsenic Trioxide results in increased degradation of PARP1 proteinPMID:16166054
PARP1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of PARP1 protein; Arsenic Trioxide results in increased expression of PARP1 protein modified formPMID:25972196 PMID:27430728
PARP1multiple interactionsEXP 6480464CTD17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; 6-Aminonicotinamide inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; [Arsenic Trioxide co-treated with Bortezomib] results in increased degradation of PARP1 protein; [Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein; [Arsenic Trioxide co-treated with IL24 protein] results in decreased expression of PARP1; [Arsenic Trioxide co-treated with MIR15A co-treated with MIR16-1] results in increased cleavage of PARP1 protein; [Arsenic Trioxide co-treated with PD 173074] results in increased expression of PARP1 protein modified form; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; [Arsenic Trioxide co-treated with Plant Extracts] results in increased cleavage of PARP1 protein; [Arsenic Trioxide results in increased susceptibility to PD 173074] which results in increased expression of PARP1 protein modified form; [Dasatinib co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [Genistein co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [MARVELD1 protein results in decreased susceptibility to Arsenic Trioxide] which results in decreased cleavage of PARP1 protein; [monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [PD 173074 results in increased susceptibility to Arsenic Trioxide] which results in increased expression of PARP1 protein modified form; [pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein; [pifithrin co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein]; Acetylcysteine inhibits the reaction [Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]]; Arsenic Trioxide promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of PARP1 protein modified form]; Arsenic Trioxide promotes the reaction [Dasatinib results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Matrines results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Zoledronic Acid results in increased cleavage of PARP1 protein]; Arsenic Trioxide results in increased cleavage of and results in increased activity of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]; Dasatinib promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Deoxyglucose inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; GSTP1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; HSF1 protein affects the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; KNK 437 promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; MARVELD1 protein inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Matrines promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; NCF2 mutant form inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; PRDX3 protein affects the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; TGIF1 mutant form promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; TGIF1 protein inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]PMID:12883035 PMID:16328441 PMID:17237268 PMID:17495969 PMID:18022205 PMID:18281123 PMID:19371599 PMID:19408305 PMID:20977926 PMID:21056550 PMID:21078540 PMID:22496356 PMID:22532027 PMID:22922937 PMID:23082001 PMID:23700110 PMID:25246272 PMID:25791921 PMID:25972196 PMID:26160715 PMID:27430728 PMID:27794399 PMID:29266867 PMID:29774349 PMID:29944906 PMID:30338810 PMID:31205918 PMID:35030298
PARP1increases activityISOParp1 (Mus musculus)6480464CTDArsenic Trioxide results in increased activity of PARP1 proteinPMID:24157283
PARP1increases cleavageISOParp1 (Mus musculus)6480464CTDArsenic Trioxide results in increased cleavage of PARP1 proteinPMID:15761769 PMID:21565247 PMID:29767511
PARP1increases cleavageISOParp1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased cleavage of PARP1 proteinPMID:24634002 PMID:32096187
PARP1increases expressionISOParp1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of PARP1 protein modified formPMID:29095437
PARP1increases expressionISOParp1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of PARP1 proteinPMID:28391263
PARP1multiple interactionsISOParp1 (Mus musculus)6480464CTD[Genistein co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Drugs, Chinese Herbal results in increased cleavage of PARP1 protein]; Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]; Glucose deficiency inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]; Rotenone inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]PMID:21078540 PMID:21565247 PMID:24157283 PMID:28587418 PMID:29095437
PARP1multiple interactionsISOParp1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein]PMID:24634002 PMID:28391263
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