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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332548
Species: Mus musculus
RGD Object: Gene
Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of PPARGC1A proteinPMID:29867492
Ppargc1aincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of PPARGC1A mRNAPMID:30362509
Ppargc1amultiple interactionsEXP 6480464CTDsalvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARGC1A protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of PPARGC1A mRNA]PMID:29867492 PMID:30362509
Ppargc1adecreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of PPARGC1A proteinPMID:29867492
Ppargc1aincreases expressionISOPPARGC1A (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of PPARGC1A mRNAPMID:20458559
Ppargc1amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTDsalvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARGC1A protein]PMID:29867492
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