GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nlrp3 | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of NLRP3 protein | PMID:30237538 PMID:35226250 | Nlrp3 | multiple interactions | EXP | | 6480464 | CTD | [Arsenic Trioxide results in increased abundance of arsenite] which results in increased expression of NLRP3 mRNA; Arsenic Trioxide promotes the reaction [AS3MT protein binds to NLRP3 protein]; Arsenic Trioxide promotes the reaction [METTL14 protein binds to NLRP3 mRNA]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein] | PMID:30237538 PMID:35226250 PMID:36791901 | Nlrp3 | increases expression | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of NLRP3 protein | PMID:30660605 | Nlrp3 | increases expression | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of NLRP3 mRNA; Arsenic Trioxide results in increased expression of NLRP3 protein | PMID:35226250 | Nlrp3 | multiple interactions | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | [Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; Taurine inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein] | PMID:30660605 | Nlrp3 | multiple interactions | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein; Arsenic Trioxide promotes the reaction [AS3MT protein binds to NLRP3 protein]; Arsenic Trioxide promotes the reaction [METTL14 protein binds to NLRP3 mRNA]; AS3MT mRNA promotes the reaction [Arsenic Trioxide promotes the reaction [METTL14 protein binds to NLRP3 mRNA]]; AS3MT mRNA promotes the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein]; AS3MT mRNA promotes the reaction [Arsenic Trioxide results in increased stability of NLRP3 mRNA]; IGF2BP2 protein promotes the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein]; IGF2BP2 protein promotes the reaction [Arsenic Trioxide results in increased stability of NLRP3 mRNA]; METTL14 protein promotes the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein]; METTL14 protein promotes the reaction [Arsenic Trioxide results in increased stability of NLRP3 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein]; Taurine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein] | PMID:30237538 PMID:35226250 | | ||||||||||||||||||||||
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