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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313525
Species: Homo sapiens
RGD Object: Gene
Symbol: MKI67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MKI67decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of MKI67 mRNA; Arsenic Trioxide results in decreased expression of MKI67 proteinPMID:27318970 PMID:30091188
MKI67multiple interactionsEXP 6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Arsenic Trioxide results in decreased expression of MKI67 mRNA]PMID:27318970
MKI67decreases expressionISOMki67 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of MKI67 proteinPMID:31421153
MKI67multiple interactionsISOMki67 (Mus musculus)6480464CTDFOXO3 protein affects the reaction [Arsenic Trioxide results in decreased expression of MKI67 protein]PMID:31421153
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