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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305728
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mknk2
Name: MAPK interacting serine/threonine kinase 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mknk2decreases response to substanceISOMKNK2 (Homo sapiens)6480464CTDMKNK2 protein results in decreased susceptibility to Arsenic TrioxidePMID:18299328
Mknk2multiple interactionsISOMKNK2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK2 protein; MAPK14 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK2 protein]; MKNK2 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]PMID:18299328
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