GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rb1 | decreases expression | ISO | RB1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of RB1 protein modified form | PMID:20953137 | Rb1 | decreases phosphorylation | ISO | RB1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased phosphorylation of RB1 protein | PMID:12480548 PMID:25335113 | Rb1 | multiple interactions | ISO | RB1 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in decreased activity of CDK6 protein] which results in decreased phosphorylation of RB1 protein; Arsenic Trioxide promotes the reaction [RB1 protein binds to E2F1 protein]; Arsenic Trioxide results in increased expression of and results in increased phosphorylation of RB1 protein; TP53 protein promotes the reaction [Arsenic Trioxide results in increased expression of RB1 protein] | PMID:10850458 PMID:34042274 | |
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