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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10649
Species: Mus musculus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of GJA1 mRNAPMID:15070760 PMID:15761015 PMID:17559834
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTDacetylleucyl-leucyl-norleucinal inhibits the reaction [Arsenic Trioxide results in decreased expression of GJA1 mRNA]; leupeptin inhibits the reaction [Arsenic Trioxide results in decreased expression of GJA1 mRNA]PMID:17559834
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