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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7309846480464CTDSilicon Dioxide results in decreased expression of COL1A2 mRNA

PMID:22300531
multiple interactionsISORGD:7309856480464CTD[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL1A2 protein, HMGB1 protein promotes the reaction [[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL1A2 protein], neo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of COL1A2 protein]

PMID:27616297
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.