GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ahr | affects response to substance | ISO | Ahr (Mus musculus) | 6480464 | CTD | AHR protein affects the susceptibility to Silicon Dioxide | PMID:22273745 | Ahr | increases activity | ISO | Ahr (Mus musculus) | 6480464 | CTD | Silicon Dioxide results in increased activity of AHR protein | PMID:30203046 | Ahr | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which co-treated with Silicon Dioxide] results in increased secretion of IL22 protein; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [Silicon Dioxide results in increased secretion of IL6 protein]; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased susceptibility to Silicon Dioxide; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of STAT5A mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CXCL1 protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IFNG protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; AHR protein affects the reaction [Silicon Dioxide results in decreased secretion of IFNG protein]; AHR protein affects the reaction [Silicon Dioxide results in decreased secretion of IL10 protein]; AHR protein affects the reaction [Silicon Dioxide results in increased secretion of CCL2 protein]; AHR protein affects the reaction [Silicon Dioxide results in increased secretion of CXCL1 protein]; AHR protein affects the reaction [Silicon Dioxide results in increased secretion of IL1B protein]; AHR protein affects the reaction [Silicon Dioxide results in increased secretion of IL6 protein]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CXCL1 protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IFNG protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]]; IL10 protein promotes the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein]] | PMID:22273745 | | ||||||||||||||||||||||
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