GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NLRP3 | affects localization | EXP | | 6480464 | CTD | Silicon Dioxide affects the localization of NLRP3 protein | PMID:34766707 | NLRP3 | increases expression | EXP | | 6480464 | CTD | Silicon Dioxide results in increased expression of NLRP3 mRNA; Silicon Dioxide results in increased expression of NLRP3 protein | PMID:33012733 PMID:34766707 PMID:34969174 | NLRP3 | multiple interactions | EXP | | 6480464 | CTD | [Silicon Dioxide co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; Desipramine inhibits the reaction [Silicon Dioxide results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Silicon Dioxide results in increased expression of NLRP3 protein]; SCGB1A1 protein inhibits the reaction [Silicon Dioxide results in increased expression of NLRP3 protein] | PMID:18604214 PMID:33012733 PMID:34969174 | NLRP3 | increases expression | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | Silicon Dioxide results in increased expression of NLRP3 mRNA | PMID:21602193 | NLRP3 | increases expression | ISO | Nlrp3 (Mus musculus) | 6480464 | CTD | Silicon Dioxide results in increased expression of NLRP3 mRNA; Silicon Dioxide results in increased expression of NLRP3 protein | PMID:36309172 | NLRP3 | multiple interactions | ISO | Nlrp3 (Mus musculus) | 6480464 | CTD | NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Silicon Dioxide results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Silicon Dioxide results in increased secretion of IL1B protein]; PINK1 protein inhibits the reaction [Silicon Dioxide results in increased expression of NLRP3 mRNA]; PINK1 protein inhibits the reaction [Silicon Dioxide results in increased expression of NLRP3 protein] | PMID:18403674 PMID:18604214 PMID:36309172 | | ||||||||||||||||||||||
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