GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | decreases expression | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Silicon Dioxide results in decreased expression of SIRT1 protein | PMID:31082419 | Sirt1 | increases expression | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide results in increased expression of SIRT1 mRNA | PMID:25351596 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]]; pyrazolanthrone inhibits the reaction [Silicon Dioxide results in decreased expression of SIRT1 protein]; Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]; Silicon Dioxide promotes the reaction [SIRT1 protein binds to TP53 protein]; Silicon Dioxide results in decreased expression of and affects the localization of SIRT1 protein; SIRT1 protein inhibits the reaction [Silicon Dioxide results in increased acetylation of and results in increased phosphorylation of and affects the localization of TP53 protein]; SIRT1 protein inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 protein modified form]; SIRT1 protein inhibits the reaction [Silicon Dioxide results in increased expression of PARP1 protein modified form] | PMID:31082419 | | ||||||||||||||||||||||
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