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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11340
Species: Mus musculus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1increases expressionEXP 6480464CTDSilicon Dioxide results in increased expression of SPP1 mRNA; Silicon Dioxide results in increased expression of SPP1 proteinPMID:26345256 PMID:26955063 PMID:29341224
Spp1multiple interactionsEXP 6480464CTDEstrogens inhibits the reaction [Silicon Dioxide results in increased expression of SPP1 protein]PMID:26955063
Spp1decreases expressionISOSPP1 (Homo sapiens)6480464CTDSilicon Dioxide results in decreased expression of SPP1 mRNAPMID:19428942
Spp1increases expressionISOSpp1 (Rattus norvegicus)6480464CTDSilicon Dioxide results in increased expression of SPP1 mRNAPMID:22431001
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