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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:3023
Term: benzbromarone
Definition: 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.
Chemical ID: MESH:D001553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2multiple interactionsEXP 6480464CTD[Benzbromarone results in decreased activity of ABCC2 protein] inhibits the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin CalciumPMID:19782883 PMID:19853032
Abcc2decreases activityISOABCC2 (Homo sapiens)6480464CTDBenzbromarone results in decreased activity of ABCC2 proteinPMID:22646477
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTDBenzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]PMID:31348918
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