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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11094
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb4
Name: ATP-binding cassette, sub-family B member 4
Acc ID: CHEBI:3023
Term: benzbromarone
Definition: 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.
Chemical ID: MESH:D001553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb4decreases activityISOABCB4 (Homo sapiens)6480464CTDBenzbromarone results in decreased activity of ABCB4 proteinPMID:28437613
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