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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736468
Species: Homo sapiens
RGD Object: Gene
Symbol: PLAT
Name: plasminogen activator, tissue type
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLATincreases expressionISOPlat (Rattus norvegicus)6480464CTDZinc deficiency results in increased expression of PLAT mRNAPMID:19111725
PLATincreases expressionISOPlat (Mus musculus)6480464CTDZinc results in increased expression of PLAT mRNAPMID:21615740
PLATincreases secretionISOPlat (Mus musculus)6480464CTDZinc results in increased secretion of PLAT proteinPMID:21615740
PLATmultiple interactionsISOPlat (Rattus norvegicus)6480464CTDZinc inhibits the reaction [Zinc deficiency results in increased expression of PLAT mRNA]PMID:19111725
PLATmultiple interactionsISOPlat (Mus musculus)6480464CTD4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT protein]; BDNF protein affects the reaction [Zinc results in increased expression of PLAT mRNA]; BDNF protein affects the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT protein]; staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT protein]; Tetanus Toxin inhibits the reaction [Zinc results in increased secretion of PLAT protein]; Zinc results in increased expression of and results in increased activity of PLAT proteinPMID:21615740
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