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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736021
Species: Homo sapiens
RGD Object: Gene
Symbol: APP
Name: amyloid beta precursor protein
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APPaffects bindingEXP 6480464CTDAPP protein binds to Zinc; APP protein modified form binds to Zinc; Zinc binds to APP protein; Zinc binds to APP protein alternative formPMID:15699049 PMID:16266835 PMID:16404590 PMID:17119284 PMID:24855651
APPincreases degradationEXP 6480464CTDZinc results in increased degradation of APP protein modified formPMID:18068270
APPincreases secretionEXP 6480464CTDZinc results in increased secretion of APP protein alternative formPMID:16648635
APPmultiple interactionsEXP 6480464CTDClioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; Zinc binds to and affects the folding of APP protein; Zinc inhibits the reaction [APP protein modified form results in increased reduction of Copper]; Zinc inhibits the reaction [APP protein results in increased reduction of Copper]; Zinc promotes the reaction [APP protein binds to APLP1 protein]; Zinc promotes the reaction [APP protein binds to APLP2 protein]; Zinc promotes the reaction [APP protein binds to APP protein]; Zinc promotes the reaction [Heparin binds to APP protein]PMID:12572668 PMID:16325427 PMID:16648635 PMID:24855651 PMID:25835329
APPincreases expressionISOApp (Rattus norvegicus)6480464CTDZinc deficiency results in increased expression of APP mRNAPMID:19111725
APPmultiple interactionsISOApp (Rattus norvegicus)6480464CTD[Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of PotassiumPMID:16674922
APPmultiple interactionsISOApp (Mus musculus)6480464CTD[APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified formPMID:15677459
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