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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730892
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKB1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKB1affects localizationEXP 6480464CTDZinc deficiency affects the localization of NFKB1 proteinPMID:21600978
NFKB1decreases expressionEXP 6480464CTDZinc results in decreased expression of NFKB1 proteinPMID:16472982
NFKB1multiple interactionsEXP 6480464CTD[Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of NFKB1 protein; Acetylcysteine inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein]PMID:17029595 PMID:18615482 PMID:21600978
NFKB1multiple interactionsISONfkb1 (Rattus norvegicus)6480464CTD[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Zinc binds to Curcumin] which affects the expression of NFKB1 mRNAPMID:19589337 PMID:37415728
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