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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDZinc results in decreased activity of GSR proteinPMID:22127830
Gsrmultiple interactionsEXP 6480464CTD[Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of GSR protein]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in decreased activity of GSR protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; [Zinc Sulfate results in increased abundance of Zinc] which results in decreased activity of GSR protein; Zinc affects the reaction [sodium arsenite results in decreased activity of GSR protein]; Zinc inhibits the reaction [Indomethacin results in decreased activity of GSR protein]; Zinc inhibits the reaction [Streptozocin results in decreased activity of GSR protein]PMID:12566098 PMID:24184500 PMID:31009641 PMID:32864810
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