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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316671
Species: Homo sapiens
RGD Object: Gene
Symbol: KRT14
Name: keratin 14
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRT14affects bindingEXP 6480464CTDKRT14 protein binds to ZincPMID:23896426
KRT14increases expressionISOKrt14 (Rattus norvegicus)6480464CTDZinc deficiency results in increased expression of KRT14 mRNA; Zinc deficiency results in increased expression of KRT14 proteinPMID:16140947
KRT14increases expressionISOKrt14 (Mus musculus)6480464CTDZinc deficiency results in increased expression of KRT14 proteinPMID:12517797
KRT14multiple interactionsISOKrt14 (Rattus norvegicus)6480464CTDZinc inhibits the reaction [Zinc deficiency results in increased expression of KRT14 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of KRT14 protein]PMID:16140947
KRT14multiple interactionsISOKrt14 (Mus musculus)6480464CTD[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of KRT14 protein; TRP53 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of KRT14 protein]PMID:12517797
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