GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod1 | multiple interactions | EXP | | 6480464 | CTD | [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of SOD1 protein]; [Zinc deficiency co-treated with Ethanol] results in decreased expression of SOD1 protein | PMID:24155903 PMID:34508822 | Sod1 | affects binding | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | Zinc binds to SOD1 mutant form; Zinc binds to SOD1 protein | PMID:17888947 PMID:19325915 | Sod1 | affects folding | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | Zinc affects the folding of SOD1 protein | PMID:26694608 | Sod1 | decreases activity | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | Zinc deficiency results in decreased activity of SOD1 protein; Zinc results in decreased activity of SOD1 protein | PMID:15076160 PMID:16413754 PMID:17726312 PMID:22127830 | Sod1 | increases activity | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | Zinc deficiency results in increased activity of SOD1 protein; Zinc results in increased activity of SOD1 protein | PMID:10381190 PMID:10938463 PMID:19459437 PMID:26967026 | Sod1 | increases expression | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | Zinc results in increased expression of SOD1 mRNA | PMID:17726312 | Sod1 | multiple interactions | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | [Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of SOD1 protein]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in decreased activity of SOD1 protein]; [Zinc co-treated with Chromium] results in increased activity of SOD1 protein; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD1 protein]; [Zinc deficiency co-treated with Chromium] results in increased activity of SOD1 protein; Dexamethasone inhibits the reaction [Zinc deficiency results in increased activity of SOD1 protein]; Thyroxine inhibits the reaction [Zinc deficiency results in increased activity of SOD1 protein]; Zinc affects the reaction [sodium arsenite results in decreased activity of SOD1 protein] | PMID:10381190 PMID:19459437 PMID:22534743 PMID:24184500 | Sod1 | multiple interactions | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | [Copper co-treated with Cadmium co-treated with Zinc] results in decreased activity of SOD1 protein; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine binds to Zinc] inhibits the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]; [SOD1 protein mutant form inhibits the reaction [Zinc binds to SOD1 protein]] promotes the reaction [SOD1 protein mutant form binds to SOD1 protein]; Cadmium Chloride inhibits the reaction [Zinc binds to SOD1 protein]; Cadmium inhibits the reaction [Zinc binds to SOD1 protein]; SOD1 gene mutant form inhibits the reaction [Zinc binds to SOD1 protein]; SOD1 protein mutant form inhibits the reaction [SOD1 protein binds to Zinc]; SOD1 protein mutant form inhibits the reaction [Zinc binds to SOD1 protein]; Zinc binds to and affects the folding of and affects the stability of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein] | PMID:16440303 PMID:16583143 PMID:17888947 PMID:19227972 PMID:19635794 PMID:26694608 PMID:31162603 PMID:33774064 | | ||||||||||||||||||||||
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